承华薇;曾蓉;李冬冬;

• 1:中国科学技术大学附属第一医院安徽省肿瘤医院药剂科
• 2:中国科学技术大学附属第一医院安徽省肿瘤医院麻醉科

摘要(Abstract)：

目的探讨细胞色素P4503A4酶(CYP3A4)CYP3A4~*1G、儿茶酚胺氧位甲基转移酶(COMT)COMT val158met、μ阿片受体编码基因1(OPRM1)OPRM1A118G的单核苷酸多态性(Single Nucleotide Polymorphism,SNP)对胃癌患者术后舒芬太尼镇痛效应的影响。方法选取2019年7月至2019年12月在中国科学技术大学附属第一医院行全胃切除术的70例患者的新鲜血液,术后给予舒芬太尼进行镇痛,采用一代(Sanger)测序方法对抽取的血样进行分析,比较患者术后24 h的VAS评分、舒芬太尼使用剂量及相关不良反应。结果 70例患者中,CYP3A4~*1G、COMT val158met、OPRM1A118G的SNPs均符合Hardy-Weinberg平衡,各基因型患者术后24 h VAS评分比较,差异有统计学意义(P<0.05),术后舒芬太尼使用剂量比较,差异有统计学意义(P<0.05),不良反应比较,差异无统计学意义(P>0.05)。结论 CYP3A4~*1G、COMT val158met、OPRM1A118G 3种基因突变型患者术后舒芬太尼镇痛给药剂量较多,患者对疼痛耐受力更低,患者不良反应发生情况相似。

关键词(KeyWords)： 基因多态性;术后镇痛;舒芬太尼

Abstract:

Keywords:

基金项目(Foundation): 中国科学技术大学“科大新医学”联合基金项目(WK9110000015)

作者(Author): 承华薇;曾蓉;李冬冬;

Email:

DOI: 10.14053/j.cnki.ppcr.202101007

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