橙皮素的大鼠血浆蛋白结合率研究Study on plasma protein binding rate of hesperetin in rat' plasma
李元辉;
摘要(Abstract):
目的测定橙皮素的大鼠血浆蛋白结合率。方法采用平衡透析法结合高效液相色谱法(HPLC)对橙皮素与大鼠血浆的血浆蛋白结合率进行测定。结果在0.5、2.5和10μg/m L浓度水平橙皮素与大鼠血浆的血浆蛋白结合率分别为(93.5±4.2)%,(94.3±5.6)%和(93.9±3.8)%,三个浓度水平之间的血浆蛋白结合率差异无统计学意义(P≥0.05)。结论橙皮素与大鼠血浆蛋白高度结合。
关键词(KeyWords): 橙皮素;血浆蛋白结合率;大鼠;平衡透析法;高效液相色谱法
基金项目(Foundation):
作者(Author): 李元辉;
Email:
DOI: 10.14053/j.cnki.ppcr.201509020
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