多囊卵巢综合征治疗药物进展Advances in the treatment of polycystic ovary syndrome
刘治国;朱玲琦;祝德秋;
摘要(Abstract):
多囊卵巢综合征(Polycystic ovary syndrome,PCOS)是女性常见的内分泌疾病,其临床表现多样。生活方式的调整和减肥是PCOS的基础治疗,可以改善多种临床症状。口服避孕药可用于调整月经周期和改善高雄激素血症。抗雄激素药物有氟他胺、非那雄胺、螺内酯等,可单用或与口服避孕药合用。枸橼酸氯米芬是促排卵的一线药物,芳香化酶抑制剂是有前景的促排卵药,在疗效和不良反应等方面可能优于枸橼酸氯米芬。改善PCOS患者的胰岛素抵抗也很重要,二甲双胍为一线药物,噻唑烷二酮类药物引起体重增加等不良反应限制了其应用,新型降糖药GLP-1可以有效地降低PCOS患者体重。有研究他汀类用于治疗PCOS,但证据尚不充分。
关键词(KeyWords): 多囊卵巢综合征;促进排卵;胰岛素增敏剂
基金项目(Foundation):
作者(Author): 刘治国;朱玲琦;祝德秋;
Email:
DOI: 10.14053/j.cnki.ppcr.201509027
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