右美托咪定与局麻药联合应用进展Progress of combined application of dexmetomidine and local anesthetics
王牧野;谭晶;张瑜;崔晓光;
摘要(Abstract):
局部麻醉药能够阻断神经冲动的发生与传递,可逆性地引起感觉缺失,从而产生麻醉效果。然而,以往局部麻醉药物作用时间较短,术后镇痛效果不佳,限制了局麻药物的应用。随着近年来医疗行业的飞速发展以及众多药物的不断出现,临床上多以局麻药物与辅助药物联合应用的方式,获得更为良好的镇痛效果的同时减少了药物的用量。多项研究表明,右美托咪定作为一种高选择性的α_2肾上腺受体激动剂,以不同的方式与局麻药配伍应用后,可不同程度地影响其起效时间、作用时效、作用效果等。本文主要就右美托咪定与局麻药物联合应用的进展进行综述。
关键词(KeyWords): 右美托咪定;局麻药;镇痛
基金项目(Foundation): 黑龙江省自然科学基金(QC2015125);; 哈尔滨医科大学附属第二医院科研创新基金(KYBS201505)
作者(Author): 王牧野;谭晶;张瑜;崔晓光;
Email:
DOI: 10.14053/j.cnki.ppcr.201905023
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