罗秀军;孙瑞红;

• 1:哈尔滨医科大学附属第一医院神经内科

摘要(Abstract)：

血管平滑肌细胞(Vascular smooth muscle,VSMC)是构成血管壁的重要成分。在动脉粥样硬化(Atherosclerosis,AS)病变中,VSMC在病理状态下凋亡失平衡引起血管重塑,导致动脉粥样硬化的发生。目前研究发现,细胞凋亡在动脉粥样硬化形成的发病和治疗中具有重要意义,而泛素-蛋白酶体抑制剂(The ubiquitinproteasome inhibitor,UPI)能够促进VSM C凋亡进而影响动脉粥样硬化。本文对泛素-蛋白酶体抑制剂影响VSM C凋亡的机制进行了综述。

关键词(KeyWords)： 泛素-蛋白酶体抑制剂;血管平滑肌细胞;凋亡

Abstract:

Keywords:

基金项目(Foundation): 黑龙江省自然科学基金(H201306)

作者(Author): 罗秀军;孙瑞红;

Email:

DOI: 10.14053/j.cnki.ppcr.201509025

参考文献(References)：

• [1]Jung T,Catalgol B,Grune T.The proteasomal system[J].Mol Aspects M ed,2009,30:191-296.
• [2]Tan C,Li Y,Tan X,et al.Inhibition of the ubiqutin-proteasome syetem:a new avenue for atherosclerosis[J].Chin Chem Lab M ed,2006,44(10):1218-1225.
• [3]Salabei JK,Cummins TD,Singh M,et al.PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress[J].Biochem J,2013,451(3):375-388.
• [4]Mack CP.Signaling mechanisms that regulate smooth muscle cell differentiation[J].Arterioscler Thromb Vasc Biol,2011,31:1495-1505.
• [5]Rivard A,Andrs V.Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases[J].Histol Histopathol,2000,15(2):557-571.
• [6]Karagiannis GS,Weile J,Bader GD,et al.Integrative pathway dissection of molecular mechanisms of mox LDL-induced vascular smooth muscle phenotype transformation[J].BM C Cardiovasc Disord,2013,13:4.
• [7]Mayr M,Xu Q.Smooth muscle cell apoptosis in arteriosclerosis[J].Exp Gerontol,2001,36(7):969-987.
• [8]Mukhopadhyay D,Riezman H.Proteasome-independent functions of ubiquitin in endocytosis and signaling[J].Science,2007,315(5809):201-205.
• [9]Wilck N,Ludwig A.Targeting the ubiquitin-proteasome system in atherosclerosis:status quo,challenges,and perspectives[J].Antioxid Redox Signal,2014,21(17):2344-2363.
• [10]Herrmann J,Lerman LO,Lerman A.On to the road to degradation:atherosclerosis and the proteasome[J].Cardiovasc Res,2010,85(2):291-302.
• [11]Karl Stangl,Verena Stangl.The ubiquitin-proteasome pathway and endothelial(dys)function[J].Cardiovasc Res,2010,85(2):281-290.
• [12]Willis MS,Townley-Tilson WH,Kang EY,et al.Seat to destroy:the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease[J].Circ Res,2010,106(3):463-478.
• [13]Herrmann J,Soares SM,Lerman LO,et al.Potential role of the ubiquitin-proteasome system in atherosclerosis:aspects of a protein quality disease[J].J Am Coll Cardiol,2008,51(21):2003-2010.
• [14]Marfella R,D'Amico M,Di Filippo C,et al.The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes[J].Cardiovasc Diabetol,2007,6:35.
• [15]Versari D,Hermann J,Gossl M,et al.Dysregulation of the ubiquitin-proteasome system in human carotid atherosclerosis[J].Arterioscler Thromb Vasc Biol,2006,26(9):2132-2139.
• [16]Jeon KI,Jeong JY,Jue DM.Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking IκB kinase[J].Immunology,2000,164(11):5981-5989.
• [17]Herrmann J,Soares SM,Lerman LO,et al.Potential role of the ubiquitin-proteasome system in atherosclerosis:aspects of a protein quality disease[J].J Am Coll Cardiol,2008,51(21):2003-2010.
• [18]Logue SE,Martin SJ.Caspase activation cascades in apoptosis[J].Biochem Soc Trans,2008,36(Pt 1):1-9.
• [19]Kuribayashi K,Mayes PA,El-Deiry WS.What are caspases-3and 7 doing upstream of the mitochondria[J].Cancer Biol Ther,2006,5(7):763-765.
• [20]Herrmann J,Ciechanover A,Lerman LO,et al.The ubiquitinproteasome system-micro target for macro intervention[J].Int J Cardiovasc Intervent,2005,7(1):5-13.
• [21]Aghajanian C,Soignet S,Dizon DS,et al.A phase I trial of the novel proteasome in hibitor PS341 in advanced sol id tumor malignancies[J].Clin Cancer Res,2002,8(8):2505-2511.
• [22]尚秀玲,朱鹏立.细胞凋亡在动脉粥样硬化发生发展中的作用[J].福建医药杂志,2008,30(3):80-82.
• [23]郭芳,何慧,孙文清,等.MG132诱导人血管平滑肌细胞凋亡及对caspase3表达的影响[J].中国药物与临床,2009,5:381-383.