泛素-蛋白酶体抑制剂对血管平滑肌细胞凋亡的影响Effects of ubiquitin-proteasome inhibitor on apoptosis of vascular smooth muscle cells
罗秀军;孙瑞红;
摘要(Abstract):
血管平滑肌细胞(Vascular smooth muscle,VSMC)是构成血管壁的重要成分。在动脉粥样硬化(Atherosclerosis,AS)病变中,VSMC在病理状态下凋亡失平衡引起血管重塑,导致动脉粥样硬化的发生。目前研究发现,细胞凋亡在动脉粥样硬化形成的发病和治疗中具有重要意义,而泛素-蛋白酶体抑制剂(The ubiquitinproteasome inhibitor,UPI)能够促进VSM C凋亡进而影响动脉粥样硬化。本文对泛素-蛋白酶体抑制剂影响VSM C凋亡的机制进行了综述。
关键词(KeyWords): 泛素-蛋白酶体抑制剂;血管平滑肌细胞;凋亡
基金项目(Foundation): 黑龙江省自然科学基金(H201306)
作者(Author): 罗秀军;孙瑞红;
Email:
DOI: 10.14053/j.cnki.ppcr.201509025
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