郭哲;高兴华;夏立新;王雅坤;马丽娟;何春涤;陈洪铎;

• 1:中国医科大学附属第一医院皮肤科

摘要(Abstract)：

目的探讨甘草甜素对接触性皮炎小鼠表皮内结合珠蛋白的影响。方法 126只接触性皮炎小鼠分别给予生理盐水、不同剂量的甘草甜素及地塞米松。采用RT-PCR和原位杂交的方法检测接触性皮炎小鼠表皮内结合珠蛋白的表达。结果甘草甜素5 mg/kg和10 mg/kg组,激发后24和48 h表皮内结合珠蛋白表达增强,甘草甜素80 mg/kg组和地塞米松1 mg/kg组,激发后24和48 h表皮内结合珠蛋白表达减弱或消失。结论低剂量甘草甜素能增强接触性皮炎小鼠表皮内结合珠蛋白的表达,而高剂量甘草甜素则减弱结合珠蛋白的表达。

关键词(KeyWords)： 甘草甜素;结合珠蛋白;接触性皮炎

Abstract:

Keywords:

基金项目(Foundation): 辽宁省教育厅创新团队科研基金(LT2010107);; 辽宁省科技厅科研基金(20102265)

作者(Author): 郭哲;高兴华;夏立新;王雅坤;马丽娟;何春涤;陈洪铎;

Email:

DOI: 10.14053/j.cnki.ppcr.2012.11.032

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