头孢他美酯干混悬剂致肝损伤一例Hepatic adverse drug reaction due to cefetamet pivoxil hydrochloride for suspension
何丽媛;
摘要(Abstract)：
1例38岁女性患者因咳嗽、憋气、胸痛、发热给予安素美干混悬剂(头孢他美酯)0.36 g,2次/d,连续服用5 d后出现稀便及恶心症状。实验室检查结果为血WBC 9.52×109/L,E 0.30;生化检查:ALT 193 U/L、AST 83 U/L、ALP 117 U/L、GGT 57 U/L。结合其他检查,判断患者肺炎已基本痊愈;肝损伤可能由安素美干混悬剂引起,遂停用。同时,给予易善复0.456 g联合维生素C 0.2 g,3次/d,21 d后恢复正常。
关键词(KeyWords)： 头孢他美酯干混悬剂;不良反应;肝损伤
基金项目(Foundation):
作者(Author): 何丽媛;
Email:
DOI: 10.14053/j.cnki.ppcr.2012.12.018
参考文献(References)：
- [1]何礼贤,陈雪华.社区获得性肺炎病原谱构成及初始经验性抗菌药物应用的争议[J].中国实用内科杂志,2007,27(2):110-113.
- [2]Noh K,Kim E,Kang W.Quantitative determination of cefe-tamet in human plasma by liquid chromatography–mass spec-trometry[J].Biomed Chromatogr,2011,25(7):779-782.
- [3]Kwon H,Lee SH,Kim SE,et al.Spontaneously reported hepat-ic adverse drug events in Korea:multicenter study[J].J Korean Med Sci,2012,27(3):268-273.
- [4]Thiim M,Friedman LS.Hepatotoxicity of antibiotics and anti-fungals[J].Clin Liver Dis,2003,7(2):381-399.
- [5]Yilmaz B,Ekz F,Coban S,et al.Cefixime-induced hepatotoxic-ity[J].Turk J Gastroenterol,2011,22(4):445.
- [6]Ekiz F,Uskudar O,Simsek Z,et al.Cefuroxime axetil-induced liver failure[J].Ann Hepatol,2010,9(3):306.
- [7]Peker E,Cagan E,Dogan M.Ceftriaxone-induced toxic hepati-tis[J].Word J Gastroenterol,2009,15(21):2669-2671.