于楠;边原;

• 1:电子科技大学医学院
• 2:四川省医学科学院·四川省人民医院/电子科技大学附属医院药学部个体化药物治疗四川省重点实验室

摘要(Abstract)：

药物在肝脏代谢过程中除代谢酶参与外,药物转运体同样也起着举足轻重的作用。除他汀类、沙坦类等心血管系统化学药对转运体会产生影响外,近年来的研究表明,一些常用于治疗心血管系统疾病的中药组分亦会影响转运体的摄取外排功能,在与西药联合应用的过程中,可能会对介导西药的肝脏转运体产生影响,从而引起药动学改变而增加药品不良反应的发生。本文从治疗心血管系统疾病的常用中药组分对转运体的影响和与其他药物联用时可能发生的药物相互作用进行介绍,为临床提高药物治疗的有效性和安全性提供依据。

关键词(KeyWords)： 中药;组分;转运体;调节

Abstract:

Keywords:

基金项目(Foundation): 四川省卫生和计划生育委员会科研课题(16PJ479);; 国家临床药学重点专科建设项目(30305030698);; 四川省省级公益性科研院所基本科研业务专项课题(2018YSKY0017)

作者(Author): 于楠;边原;

Email:

DOI: 10.14053/j.cnki.ppcr.201905025

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