许涛;王慧莹;徐爱茹;赵楚敏;宋月霞;李莉;

• 1:河北省唐山市人民医院心内二科

摘要(Abstract)：

目的观察不同类型心房颤动(简称房颤)患者血浆儿茶酚抑素水平的变化,分析儿茶酚抑素水平对房颤发生的意义,并初步探讨其可能机制。方法回顾性分析2015年6月至2016年12月我院心内科治疗的房颤患者78例,将其作为房颤组,依据其类型不同分为阵发性房颤组(PAF组)49例及慢性房颤组(CAF组)29例;选取同期合并疾病相似,但无心房颤动病史的窦性心律患者50例作为对照组,记录其入院资料以及相关检查指标,检测血浆儿茶酚抑素水平;同时追踪随访治疗1个月后患者超声心动图检查指标及血浆儿茶酚抑素水平。依据房颤组患者随访时房颤是否转复,将其分为转复组(C组)及房颤发作组(D组)。结果与对照组比较,房颤组患者心率增快,收缩压与左室射血分数(LVEF)降低,左房前后径(LAD)增大,N末端脑钠肽前体(NTproBNP)升高,差异有统计学意义(P<0.05)。房颤组血浆儿茶酚抑素水平明显低于对照组,差异有统计学意义(P<0.05),而CAF组与PAF组比较差异无统计学意义(P>0.05)。治疗1个月后,转复组LVEF较房颤发作组明显升高,差异有统计学意义(P<0.05),两组血浆儿茶酚抑素水平比较差异无统计学意义(P>0.05)。转复组LVEF与对照组比较,差异无统计学意义(P>0.05),儿茶酚抑素水平低于对照组,差异有统计学意义(P<0.05)。结论血浆儿茶酚抑素水平变化可影响房颤的发生,血浆儿茶酚抑素水平降低可能是房颤形成潜在的独立预测因素,且心房颤动与儿茶酚抑素的关系不受左室射血分数的影响。

关键词(KeyWords)： 儿茶酚抑素;心房颤动;发生机制

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 许涛;王慧莹;徐爱茹;赵楚敏;宋月霞;李莉;

DOI: 10.14053/j.cnki.ppcr.201803008

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